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Updated: Jul 23, 2025

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精子是自然抑制AR信号在割抵抗性前列腺癌的自然抑制剂

Xiao Li1, Fei Li2, Fei Ye3

  • 1School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.

Cell reports
|July 15, 2023
PubMed
概括

作为前列腺代谢物,精子胺通过阻断蛋白质氨酸甲基转移酶1 (PRMT1) 和雄激素受体 (AR) 信号传递,抑制了抵抗割的前列腺癌 (CRPC) 的生长. 这为克服当前基于AR的CRPC疗法的局限性提供了一个新的策略.

关键词:
在AR-FL的基础上.在AR-V7中使用AR-V7.CP: 癌症 癌症 癌症在CRPC中使用CRPC.代谢产物的代谢物在PRMT1中,精子中的精子.

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