探索失调的免疫反应基因和内皮功能障碍生物标志物作为严重COVID-19的预测因素
Fabiane S Reis-Goes1, Nívia N Silva1, Taiane M Gondim1
1Department of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, Brazil; Postgraduate Program in Immunology, Health Sciences Institute, Federal University of Bahia, Brazil.
International immunopharmacology
|July 15, 2023
概括
生物标志物如SELPLG基因表达和可溶性PSGL-1水平,以及中性粒细胞-淋巴细胞比率和血小板-淋巴细胞比率,预测严重的COVID-19. 这些免疫反应和内皮功能障碍的指标有助于患者监测和临床管理.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 临床医学 临床医学
背景情况:
- 识别严重的COVID-19病例对全球健康至关重要.
- 需要有效的生物标志物用于临床管理和预测结果.
- 免疫反应基因和内皮标记可能表明疾病的严重程度.
研究的目的:
- 研究白细胞中免疫反应基因 (ARG1,NOS2,ITGA4,SELPLG) 的表达.
- 测量P-选择素和PSGL-1的血水平.
- 将这些标记与COVID-19的严重程度相关联.
主要方法:
- 这是一项对117名COVID-19患者 (58名严重,59名轻度) 的观察性研究.
- 使用RT-qPCR分析基因表达.
- 血蛋白水平通过ELISA测量.
主要成果:
- 严重的COVID-19患者年龄较大,更常见的是黑人和男性.
- 在严重病例中,中性粒细胞-淋巴细胞比率 (NLR) 和血小板-淋巴细胞比率 (PLR) 较高.
- 在严重的COVID-19中增加ARG1和SELPLG基因表达,以及更高的可溶性P-选择素和PSGL-1水平.
结论:
- NLR,PLR,SELPLG表达和可溶性PSGL-1是COVID-19严重程度的独立预测因素.
- 内皮功能障碍和白细胞反应的生物标志物与COVID-19的严重程度有关.
- 这些标志物对临床管理和患者监测有希望.
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