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血清il-18和rs187238单核酸多态性与COVID-19门诊患者的高密度脂蛋白变化有关

Glautemberg de Almeida Viana¹, Mac Dionys Rodrigues da Costa¹, Mateus Edson da Silva¹

¹Program in Pharmaceutical Sciences; Faculty of Pharmacy, Dentistry and Nursing; Federal University of Ceará, Brazil.

International immunopharmacology

|July 15, 2023

概括

介质素-18 (IL-18) 水平及其rs187238多态性与COVID-19患者中较低的高密度脂蛋白胆固醇 (HDL-c) 和无脂蛋白A-I有关. 这些发现突出了与COVID-19相关的潜在心血管风险.

科学领域:

心血管疾病研究研究
炎症疾病研究炎症疾病研究
脂蛋白代谢研究研究脂蛋白代谢研究

背景情况:

COVID-19是一种通过改变脂蛋白代谢与心血管风险相关的炎症状况.
介质素-18 (IL-18) 和其单核酸多态 (SNP) rs187238与炎症和心血管疾病的进展有关.

研究的目的:

为了研究IL-18水平,IL-18 SNP rs187238和COVID-19门诊患者的脂蛋白样本变化之间的关联.
评估COVID-19对脂质样本的影响及其与炎症标志物的相关性.

主要方法:

一项观察性,横截面研究涉及250名呼吸综合征患者,包括90名COVID-19患者.
测量血清脂质 (TC,HDL-c,LDL-c,TG),阿波利波蛋白 (Apo A-I,Apo B) 和IL-18水平. 通过测量血清脂质 (TC,HDL-c,LDL-c,TG),测量血清脂质 (TC,HDL-c,LDL-c,TG),测量血清脂质,测量血清脂质,测量血清脂质,测量血清脂质,测量血清脂质,测量血清脂质,测量血清脂质.
使用实时聚合酶连锁反应 (qPCR) 进行IL-18 SNP rs187238的基因定型.

主要成果:

在COVID-19患者中,降低了总胆固醇 (TC) 和HDL-c.
在IL-18水平和HDL-c之间观察到负相关性,与Apo B/Apo A-I比率有正相关性.
在COVID-19患者中,IL-18 SNP rs187238的CC基因型与HDL-c和Apo A-I降低有关.

结论:

在COVID-19门诊患者中,IL-18水平和rs187238多态性与减少的HDL-c和Apo A-I有关.
这些发现表明,在COVID-19的背景下,IL-18,遗传变异和不良脂蛋白概况之间存在联系,这可能表明心血管风险增加.

关键词:

在阿波利波蛋白A-I.高密度脂蛋白是一种高密度脂蛋白.一个单核酸多态性多态性.

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Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...