相关实验视频

Updated: Jul 23, 2025

Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection
08:16

Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection

Published on: July 21, 2022

1.5K

一种电友断片选,用于开发针对caspase-2的小分子

Matthew E Cuellar1, Mu Yang1, Surendra Karavadhi2

  • 1Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, 55414, USA.

European journal of medicinal chemistry
|July 15, 2023
PubMed
概括

研究人员确定了新型的小分子抑制剂,用于酶-2 (Casp2),这是一种涉及阿尔茨海默病的酶. 这些化合物显示出有希望的选择性和目标参与,为新中枢神经系统药物开发铺平了道路.

更多相关视频

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay06:17

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

Published on: February 28, 2025

596
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin06:29

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

5.6K

相关概念视频

Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
12.6K