介质素-10增强了腹部 tegmental 区域多巴胺神经元的活性,导致多巴胺释放的增加
Joakim W Ronström1, Stephanie B Williams1, Andrew Payne1
1Brigham Young University, Department of Psychology/Neuroscience, Provo, UT 84602, United States.
Brain, behavior, and immunity
|July 15, 2023
概括
抗炎性细胞因子介素-10 (IL-10) 增强了大脑中多巴胺的释放,影响了动机. 这发生在IL-10对腹部体区域的多巴胺神经元起作用,影响行为.
科学领域:
- 神经科学是一个神经科学.
- 神经免疫学 神经免疫学
- 行为科学 行为科学
背景情况:
- 从腹膜区域 (VTA) 到核 (NAc) 的多巴胺信号传递对激励至关重要.
- 神经免疫系统通过细胞因子影响神经元活动和动机状态.
- 特定的细胞因子对VTA电路和动机的影响在很大程度上仍未被探索.
研究的目的:
- 为了研究抗炎性细胞因子INTERLEUKIN-10 (IL-10) 对中边多巴胺系统活性的影响.
- 确定IL-10如何影响多巴胺传输和动机行为.
- 在VTA内确定IL-10作用的细胞点和机制.
主要方法:
- 电生理学测量神经元发射和电流.
- 神经化学测试以量化多巴胺水平.
- 免疫组织化学用于定位IL-10受体.
- 行为研究,包括有条件的地方厌恶,以评估动机变化.
主要成果:
- 介质素-10 (IL-10) 的使用增强了VTA中的多巴胺神经元的激发,并增加了NAc中的多巴胺水平.
- IL-10通过多巴胺神经元中的后突触酸3-激酶信号传递来调解其作用,减少VTA的GABAergic电流.
- 内IL-10的给药增加了NAc多巴胺水平,并在体内诱导了有条件的位置厌恶.
结论:
- 介质素-10 (IL-10) 增强了半边缘多巴胺的传播,这表明抗炎信号在调节动机过程中的作用.
- IL-10受体 (IL-10R) 存在于VTA多巴胺神经元上,表明它们是IL-10的直接目标.
- 这些发现确定了VTA中的IL-10信号作为动机状态和相关行为的潜在调节器.
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