基因和环境对初级闭角玻璃眼和初级开角玻璃眼的贡献:台湾的一项全国性研究
Jiahn-Shing Lee1, Chang-Fu Kuo2, Wei-Min Chen3
1From the Department of Ophthalmology, Chang Gung Memorial Hospital (J.-S.L., K.-K.L.); College of Medicine, Chang Gung University (J.-S.L., K.-K.L.).
American journal of ophthalmology
|July 15, 2023
概括
遗传因素对原发性开角青光眼 (POAG) 有显著的贡献,而环境因素对原发性闭角青光眼 (PACG) 有更大的影响. 本研究量化了这些家族风险及其潜在原因.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 玻璃眼,不可逆转失明的主要原因,包括初级闭角玻璃眼 (PACG) 和初级开角玻璃眼 (POAG).
- 了解这些青光眼亚型的家族聚合和病因因素对于风险评估和预防策略至关重要.
研究的目的:
- 估计与PACG和POAG相关的家族风险.
- 确定遗传和环境因素对PACG和POAG发展的相对贡献.
主要方法:
- 一个回顾性,基于人口的队列研究,利用台湾国家健康保险计划数据库 (2000-2017年).
- 纳入4,144,508个家庭 (23,373,209个个体),以使用多基因责任模型评估青光眼的遗传性和家族传播.
- 考克斯的比例危险模型被用来计算那些被诊断患有青光眼的第一级亲属的人的调整相对风险.
主要成果:
- 与一般人群相比,患有PACG的一级亲属的个人患PACG的风险高出2.44倍.
- 与普通人群相比,患有POAG的一级亲属的人患POAG的风险是6.66倍.
- 添加基因变异为PACG贡献了19.4%,为POAG贡献了59.6%,而共同的环境因素则为PACG贡献了19.1%,为POAG贡献了23.2%.
结论:
- 遗传因素在POAG病因学中起着更重要的作用.
- 在PACG的发展过程中,环境因素似乎更为关键.
- 未来的研究应该优先确定PACG的新环境决定因素.
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