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Updated: Jul 23, 2025

Traumatic Peripheral Nerve Injury in Mice
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神经修复和重建的挑战

James S Lin1, Sonu A Jain2

  • 1Department of Orthopaedics, The Ohio State University Wexner Medical Center, 241 West 11th Avenue, Suite 6081, Columbus, OH 43201, USA.

Hand clinics
|July 15, 2023
PubMed
概括

周围神经受伤对生活质量产生重大影响,尽管得到治疗,但结果往往很差. 目前的选择,如直接修复和神经自移植有局限性,推动研究神经转移和未来的再生疗法.

关键词:
神经移植是一种神经移植.神经的重建 神经的重建神经修复神经的修复.神经传递神经传递周围神经受伤的情况.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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