模拟将5 760项临床研究在5个外科专业的实践中采用
Moustafa Abdalla1, Salwa Abdalla2, Mohamed Abdalla2
1Department of Surgery, Harvard Medical School, Harvard University, Boston, Massachusetts; Computational Statistics and Machine Learning Group, Department of Statistics, University of Oxford, Oxford, UK.
The Journal of surgical research
|July 15, 2023
概括
这项研究模拟了临床研究在外科实践中的采用,并发现了根据专业的显著差异. 妇科科的引用率和指导方针的采用率较高,而大多数临床试验并未纳入护理点参考.
科学领域:
- 医学研究翻译 医学研究翻译
- 手术实践的采用 手术实践的采用
- 临床知识综合 临床知识综合
背景情况:
- 对影响新知识融入术后护理标准的因素的理解有限.
- 需要模拟临床研究在外科实践中的采用,并确定影响翻译延迟的可修改因素.
研究的目的:
- 在外科手术实践中采用临床研究的模式.
- 确定影响研究翻译延迟的可修改因素.
- 提出新的影响指数,以优先考虑外科文学.
主要方法:
- 对UpToDate文章 (2011-2020年) 的分析,以评估在 point-of-care的研究纳入.
- 五个外科专业的5760个新参考文献与未引用的文章进行了比较.
- 引用率的量化,引用时间,以及影响因子,地理位置和资金的影响.
主要成果:
- 在不同外科专业之间观察到研究采用的显著差异.
- 尽管证据质量较差,但外科病例报告被高度引用;大多数临床试验 (94%-100%) 并未纳入.
- 实用试验显示引用率高 (40%);期刊影响因子与引用率不一致相关.
- 妇科科的引用率高出5倍,高质量的证据得到了更多的纳入,实践指南得到了更好的采用.
结论:
- 了解翻译延迟对于识别在外科实践中采用研究的障碍至关重要.
- 该研究提出了监测研究投资效率和评估研究翻译政策的新方法.
- 解决转化延迟可能会改善手术结果和研究投资回报.
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