肠道微生物组和肠道衰竭相关的肝病
Lu Jiang1, Juan Xu2, Si-Yang Cheng3
1Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China; Shanghai Institute for Pediatric Research, Shanghai 200092, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China.
概括
肠道失调在肠道衰竭相关肝病 (IFALD) 的发展中至关重要. 本综述探讨了肠道微生物群的变化和有针对性的干预措施,以优化腹腔营养诱导的肝损伤.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 与肠道衰竭相关的肝病 (IFALD) 是长期亲肠道营养 (PN) 的常见并发症.
- IFALD包括一系列的肝脏疾病,从胆固醇病到肝硬化.
- 肠道失调是IFALD发病和进展的一个关键因素.
研究的目的:
- 审查IFALD中的肠道微生物群的分类学和功能性变化.
- 检查微生物代谢物和信号通路在IFALD中的作用.
- 为PN诱导的肝损伤提供针对微生物群的干预措施的观点.
主要方法:
- 关于IFALD和肠道微生物群的临床前和临床研究的文献综述.
- 在IFALD中分析肠道微生物群的组成和功能.
- 评价微生物代谢物和信号在IFALD的病原性.
主要成果:
- 在IFALD中一直观察到肠道失调.
- 微生物代谢物和信号通路显著影响IFALD的进展.
- 微生物群操纵策略在IFALD中显示出可变的有效性.
结论:
- 肠道微生物群在IFALD的发病过程中发挥着关键作用.
- 准肠道微生物群为IFALD提供了潜在的治疗策略.
- 需要进一步的研究来优化PN诱导的肝损伤通过微生物群调节.
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