在生殖后的雌性小鼠中,与时间和生殖衰老相关的氧化应激抵抗的变化
Tristin L King1, Kaden B Underwood1, Kindra K Hansen1
1College of Veterinary Medicine, Department of Veterinary Clinical and Life Sciences, Center for Integrated BioSystems, Utah State University, Logan, UT, 84322, USA.
GeroScience
|July 15, 2023
概括
生殖会影响健康,但机制尚不清楚. 在小鼠中进行的卵巢组织移植揭示了在老化过程中控制氧化应激的新型,与雌激醇无关的卵巢作用.
科学领域:
- 生殖生物学 生殖生物学
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
背景情况:
- 生殖与健康和生存有关,但其代谢效应尚未完全理解.
- 氧化应激反应途径对于衰老和代谢调节至关重要.
- 卵巢在与衰老相关的氧化应激中的作用是复杂的,并未完全阐明.
研究的目的:
- 研究年轻和老卵巢组织对肝脏氧化应激反应蛋白的影响.
- 为了区分卵巢衰老与时间衰老对氧化应激的影响.
- 确定卵巢生殖细胞和雌激素在这些反应中的作用.
主要方法:
- 对不同年龄 (4,13,27个月) 的对照小鼠肝氧化应激反应蛋白的分析.
- 与年龄较大的小鼠 (23个月) 进行比较,在13个月接受年轻的卵巢组织移植 (完好或卵泡枯竭).
- 在移植接受者小鼠中测量雌激素水平.
主要成果:
- 对照小鼠在13至27个月之间显示氧化应激蛋白的显著变化,其中大多数增加.
- 年轻的卵巢组织移植导致大多数肝氧化应激蛋白减少.
- 移植对蛋白质的影响与与年龄相关的对照变化不同,并且独立于生殖细胞和雌激素.
结论:
- 卵巢在衰老过程中对氧化应激反应产生雌激醇独立的影响.
- 这种影响在生殖和后生殖阶段之间有所不同.
- 研究结果表明,卵巢在女性健康和生存方面发挥了新的作用,超出了雌二醇信号传递的范围.
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