深度学习用于尿道膀光滑肌肉的组织病理细分
Sridevi K Subramanya1, Rui Li2, Ying Wang3
1Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, 1 Lomb Memorial Drive, Rochester, NY, 14623, USA.
BMC medical informatics and decision making
|July 15, 2023
概括
自动化的深度学习模型准确地细分尿膀光滑肌肉组织. 移动NetV2和U-Net实现了高性能,有助于精确的膀癌分期.
科学领域:
- 组织病理学 组织病理学
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 准确的平滑肌肉组织学评估对于分期内部器官瘤至关重要,特别是在泌尿膀.
- 病理学家手动细分肌肉组织具有挑战性,因此对自动化系统产生了需求.
- 开发可靠的自动化光滑肌肉图像分割对于提高诊断准确性至关重要.
研究的目的:
- 描述膀中的肌肉纤维,特别是肌肉粘膜 (MM) 和肌肉自身 (MP).
- 评估和比较深度学习模型对光滑肌肉细分的性能.
- 为未来的自动化组织学细分工具建立一个基准.
主要方法:
- 评估了277张来自尿膀手术样本的组织学图像.
- 采用了两组深度学习模型:基于补丁的 (VGG16,ResNet18,SqueezeNet,MobileNetV2) 和基于像素的 (U-Net,MA-Net,DeepLabv3+,FPN).
- 在像素级别评估所有训练模型的细分性能.
主要成果:
- 移动NetV2 (基于补丁) 和U-Net (基于像素) 在对MP和非MP区域进行细分方面表现出卓越的表现.
- 实现了0.74 (MobileNetV2) 和0.79 (U-Net) 的平均杰卡德指数.
- 实现了0.82 (MobileNetV2) 和0.88 (U-Net) 的平均子系数,并对速度和准确性进行了详细的分析.
结论:
- 开发了一种有效的基于深度学习的系统,用于精确地确定膀癌的病理阶段.
- 这项研究为未来开发光滑肌肉组织学细分工具提供了基准.
- 强调深度学习在提高泌尿病恶性瘤诊断能力方面的潜力.
相关概念视频
Anatomy of the Genitourinary System II: Bladder and Urethra
138
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
138
Urinary Bladder
984
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
984
Imaging Studies I: Kidney, Ureter, and Bladder Studies
25
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
25
Ureters
574
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
574


