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在中国住院的PLWH中患病的流行率和危险因素
Naxin Zhao1, Pan Xiang1, Zhili Zeng1
1Department of Nephrology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
AIDS research and therapy
|July 15, 2023
概括
病在中国艾滋病毒感染者中很常见,特别是那些接受抗逆转录病毒疗法 (ART) 的人. 低血红蛋白水平与两组人群的病有关,老年和低白蛋白也是ART患者的危险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 病是艾滋病毒感染者 (PLWH) 的重要并发症,影响患者的治疗结果.
- 关于中国PLWH的功能存在有限的数据.
- 这项研究解决了对中国PLWH脏病患病率和风险因素的数据需求.
研究的目的:
- 评估在中国住院的PLWH中病的流行率.
- 确定与PLWH中病相关的风险因素,区分那些在抗逆转录病毒疗法 (ART) 上和未在抗逆转录病毒疗法 (ART) 上的人.
主要方法:
- 一项涉及住院成人PLWH的横截面研究.
- 通过估计的淋巴细胞过率 (eGFR) < 60 mL/min/1.73 m2 或存在血,蛋白尿或微专尿的定义的病.
- 使用后勤回归分析来确定相关的风险因素.
主要成果:
- 在501名PLWH中,病的总流行率为19.0%.
- 与不接受ART治疗 (13.7%) 的患者相比,接受ART治疗的患者患病的患病率较高 (22.6%).
- 在这两组中,低血红蛋白是病的重要危险因素. 老年和较低的白蛋白与ART患者的脏疾病有关.
结论:
- 在中国的住院PLWH中,病的患病率很高,在接受ART的人群中尤为高.
- 建议对门诊PLWH进行进一步的大规模研究,以准确确定中国一般PLWH人口的患病率.
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