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亚thalamic核深度大脑刺激对发言的长期影响在帕金森病的发言
Annalisa Gessani1, Francesco Cavallieri2,3, Valentina Fioravanti4
1Neurology Unit, Department of Neuroscience, S. Agostino Estense Hospital, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
Scientific reports
|July 15, 2023
概括
双边下丘脑核深度大脑刺激 (STN-DBS) 在晚期帕金森病 (PD) 患者中长期保持语音可理解性. 虽然急性刺激改善了语音,但与手术前水平相比,长期结果显示稳定.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 语音科学 语言科学
背景情况:
- 双边脑下核深度大脑刺激 (STN-DBS) 是晚期帕金森病 (PD) 的关键治疗方法.
- STN-DBS对PD患者的语音产生和理解能力的长期影响仍然是正在进行的研究和辩论的主题.
研究的目的:
- 研究双边STN-DBS对晚期PD患者语音可理解性的长期影响.
- 在5年的随访期间,在各种刺激和药物条件下比较语音结果.
主要方法:
- 评估了接受双边STN-DBS的25名晚期PD患者的队列.
- 在手术前和长期随访 (5年) 期间,使用感知声学分析评估语音可理解性.
- 进行了手术前和手术后的比较,考虑了不同的刺激和药物状态.
主要成果:
- 长期跟踪表明,与手术前水平相比,语音可理解性保持稳定.
- 在STN-DBS中,术后语音可理解性显著急性改善.
- 这些改善是在比较刺激/无药和非刺激/无药条件时观察到的.
结论:
- 双边STN-DBS可以有效地长期管理高级PD患者的语音可理解性.
- 研究结果表明,STN-DBS在维持语音功能方面起着至关重要的作用,即使在植入后的几年内也是如此.
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