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NAFLD与静止而不是活跃的克罗恩病有关
Scott McHenry1, Matthew Glover1, Ali Ahmed1,2
1Division of Gastroenterology, Washington University in St. Louis, St. Louis, MO, USA.
静态克罗恩病 (CD) 增加了非酒精性脂肪性肝病 (NAFLD) 的风险,独立于体重指数. 这表明CD患者中存在独特的NAFLD机制,与漏肠假说不同.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 炎症性肠道疾病研究研究
背景情况:
- 克罗恩病 (CD) 与非酒精性脂肪性肝病 (NAFLD) 的风险更高有关.
- 连接CD和NAFLD的潜在机制尚未完全理解.
研究的目的:
- 调查CD患者的活跃肠道炎症是否有助于发展NAFLD的风险.
- 探索CD和NAFLD患病率中的疾病活动之间的关系.
主要方法:
- 两个没有先前肝病的CD患者队伍接受了磁共振肠道学.
- 使用质子密度脂肪分数 (≥5.5%) 来评估NAFLD. 疾病活动通过内镜 (简单内镜评分,鲁特吉尔茨评分) 和临床指数 (哈维-布拉德肖指数) 评估.
- 还进行了细胞因子分析和肝硬度测量.
主要成果:
- 40%的患者被诊断出NAFLD,放射性静止CD患者的患病率更高 (OR=1.7,P=.01).
- 即使调整了BMI和内脏脂肪组织 (aOR=7.8,P=.03) 后,这种关联仍然显著.
- 内镜疾病活动与NAFLD相关,但临床症状没有. 干白素-8水平是NAFLD的预测,独立于BMI.
结论:
- 放射性静止的克罗恩病与NAFLD的风险增加有关.
- 这些发现表明,与普通人群相比,CD患者的NAFLD具有不同的致病途径,可能会挑战"漏肠"假说.
- 需要进一步的研究来阐明具体的机制和相关因素.
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