流量比和定位在灯塔尖端的影响ECMO返回管
Francesco Fiusco1, Julien Lemétayer2, Lars Mikael Broman3,4
1FLOW, Department of Engineering Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden. fiusco@kth.se.
Biomechanics and modeling in mechanobiology
|July 16, 2023
概括
身体外膜氧化 (ECMO) 并发症可能来自血液流动中断. 这项研究揭示了管的设计和定位如何影响ECMO治疗期间的流体动力学和血液溶解风险.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 心血管科学 心血管科学
背景情况:
- 体外膜氧化 (ECMO) 对于耐火性心肺衰竭至关重要.
- 在ECMO过程中,人工表面和生理压力会引起并发症.
- 了解ECMO成分周围的流体动力学是缓解血液损伤的关键.
研究的目的:
- 为了数值地研究灯塔周围的流体结构,以回归配置的灯塔尖直管.
- 分析流速比率和管定位对血液溶解的影响.
- 描述流体动力学和识别潜在的血液损伤来源.
主要方法:
- 实验验证的数值模拟灯塔尖头.
- 使用了水和牛顿血相似物.
- 不同的流速比率和管定位.
主要成果:
- 强大的剪切层形成在侧孔喷气遇到共同流的地方.
- 观察到静止的反流区域在管的下游.
- 倾斜的管加剧了宽侧的循环,产生了,增加了局部血液溶解风险.
- 狭窄的侧孔始终重新注入更大的液体分数.
- 一种辐射力形成,在倾斜时使管重新进入中心.
结论:
- 管的设计和定位显著影响器件内部的血液动力学.
- 侧孔附近的旋转结构构成局部血液溶解风险.
- 尽管存在局部风险,但整体血解指数在测试条件下保持稳定.
- 管在倾斜时会产生自我中心的辐射力,这可能会改善定位.
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