在发育过程中缺乏黑激素会损害大鼠的头面部和牙发作
Bruno Calsa1,2, Ludmilla Scodeler de Camargo3, Tainá Jaqueline Bortolança4
1Graduate Program of Biomedical Sciences, Hermínio Ometto Foundation - FHO, Araras, SP, Brazil.
Clinical oral investigations
|July 16, 2023
概括
在老鼠中缺乏母性黑激素 (PINX) 会降低后代的头面部和牙发育. 这突出了黑激素.
科学领域:
- 发育生物学 发展生物学
- 内分泌学 在内分泌学.
- 面研究研究 面研究
背景情况:
- 桃腺产生的荷尔蒙 - - 黑激素 (melatonin) 在各种生理过程中起作用.
- 在产前发育过程中缺乏黑色素对面和牙结构的影响尚未完全理解.
- 松切除术 (PINX) 提供了一个研究黑激素缺乏症影响的模型.
研究的目的:
- 为了研究切除术引起的黑激素缺失对Wistar大鼠后代的面和牙发育的影响.
- 评估母乳黑激素缺乏对幼关键发育参数的影响.
主要方法:
- 三组怀孕的Wistar大鼠:完好无损,松切除 (PINX) 和PINX与黑色素替代剂.
- 对7天大的幼头部进行了头脑测量和组织学分析.
- 对特定发育基因的切口和大的mRNA表达分析.
主要成果:
- 皮恩克斯幼显示神经和面部尺寸减少,膜骨面积减少,切口较小.
- 组织学分析显示,PINX幼的口腔细胞和牙层增加.
- 在PINX后代中,基因表达变化包括上调的Dmp1和Rankl,以及下调的Col1a1,Opn和Osx.
结论:
- 在早期发育过程中,母亲缺乏黑激素会对后代的牙和大的发育产生重大影响.
- 缺少黑激素可以延迟上组织的口腔生殖和骨质生殖.
- 研究结果表明,产前黑激素干扰与头骨面部变化之间存在潜在联系,这需要进一步对人类进行研究.
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