[产前检测到的大动脉形异常及其出生后的后果]
Zsolt Tidrenczel1, Erika P Tardy2, Anikó Ladányi3
11 Észak-pesti Centrumkórház - Honvédkórház, Szülészet-Nőgyógyászati Osztály, Genetikai Centrum Budapest, Podmaniczky u. 111., 1062 Magyarország.
Orvosi hetilap
|July 16, 2023
概括
胎儿的大动脉形异常与其他健康问题有关,需要仔细的产前诊断. 出生后的彻底跟踪对于管理相关疾病和确保最佳结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 产前诊断 在产前诊断
背景情况:
- 大动脉形异常常常与先天性心脏缺陷,心脏外形和染色体异常有关.
- 这些异常可能导致严重的产后并发症,如食道和气管压缩.
研究的目的:
- 为了确定患有大动脉形异常的胎儿中相关心脏和心脏外形的患病率.
- 评估这些胎儿染色体异常的频率.
- 为了评估怀孕和产后的结果.
主要方法:
- 在2016年至2020年期间进行了一项回顾性队列研究.
- 数据包括被诊断患有大动脉形异常的胎儿和来自第三级推中心的遗传检测结果.
- 产后结果收集到出生后24个月.
主要成果:
- 大动脉形异常的患病率在11,380例怀孕中为0.25%.
- 在28例右大动脉形异常病例中,33%的患者患有相关的心脏或心脏外形,包括Fallot四重症和胸腺缩.
- 在3.7%的病例中发现了22q11.2微切除. 产后诊断一致性为93%,42.9%的病例经历了气管/食道压缩.
结论:
- 胎儿大动脉形异常是一种复杂的疾病,需要通过超声波进行专家产前诊断.
- 相关异常需要全面的产科和心脏评估,侵入性产前检测和长期产后随访.
- 多学科管理对于优化受影响怀孕的结果至关重要.
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