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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy
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改善脚指甲年龄估计模型.

Kristina Fokias1, Lotte Dierckx1, Wim Van de Voorde2

  • 1KU Leuven, Forensic Biomedical Sciences, Department of Imaging & Pathology, Leuven, Belgium.

Forensic science international. Genetics
|July 16, 2023
PubMed
概括

现在可以使用指甲和脚甲的DNA甲基化模式来估计时间年龄. 这种改进的方法提高了年龄预测的准确性,即使是在死后的情况下.

科学领域:

  • 法医科学 法医科学 法医科学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 分子生物学分子生物学

背景情况:

  • 之前的研究已经确定了指甲中的DNA甲基化 (DNAm) 模式,用于计时年龄估计.
  • 在4个遗传标记中使用15个CPG的初始模型显示,平均绝对偏差 (MAD) 为7.68-9.36年.

研究的目的:

  • 用脚指甲样本提高基于DNAm的年龄估计的准确性.
  • 评估另外三种与年龄相关的标记物 (KLF14,MIR29B2CHG,TRIM59) 的疗效.

主要方法:

  • 分析了来自ASPA,EDARADD,ELOVL2,PDE4C,KLF14,MIR29B2CHG和TRIM59中的CpG的DNA甲基化数据. 这些数据包括:
  • 使用变量选择和模型构建来完善年龄预测.
  • 改进的模型在训练和测试套件上进行了测试,包括尸体样本.

主要成果:

  • 增强的年龄估计试验在训练组中实现了4.82年的MAD,在测试组中达到5.61年的MAD.
  • 该研究证明了使用这种方法用于死后年龄估计的可行性.

结论:

  • 精细的DNA甲基化试验显著提高了从脚指甲的年代年龄预测准确度.
关键词:
年龄预测年龄预测通过DNA甲基化.法医医学法医学的研究.

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  • 这种方法对法医应用有希望,包括对已故个体的年龄确定.