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肺部疾病中介质干细胞及其在COVID-19中的潜在用途 ARDS:系统化审查

Bruna Benigna Sales Armstrong¹, Juan Carlos Montano Pedroso², José da Conceição Carvalho²

¹Universidade Federal do Piauí (UFPI), Terezina, PI, Brazil.

Clinics (Sao Paulo, Brazil)

|July 16, 2023

概括

脂肪组织衍生干细胞 (ASC) 显示出治疗慢性肺部疾病和严重的COVID-19 ARDS的前景. 研究表明,ASC是安全的,可以通过调节免疫反应来减少肺损伤,但需要更多的研究.

科学领域:

再生医学是一种再生医学.
免疫学免疫学免疫学
肺部病理学肺部病理学

背景情况:

COVID-19与慢性肺部疾病共享的促炎机制.
肺移植带来了独特的挑战,其替代疗法有限.
脂肪组织衍生干细胞 (ASCs) 提供了一个潜在的治疗途径.

研究的目的:

审查ASC在治疗常规疗法不响应的肺部疾病方面的潜力.
评估ASC在治疗严重COVID-19急性呼吸困扰综合征 (ARDS) 中的适用性.

主要方法:

综合审查35项研究,包括叙事评论,临床前试验和概念证明.
对ASC的管理,安全性和肺部疾病的疗效现有数据的分析.

主要成果:

在审查的研究中,ASC的使用没有显示出严重的不良反应或毒性.
ASCs在减少肺损伤和恢复白细胞和淋巴细胞水平方面表现出潜力.
突出了ASCs的免疫调节和抗亡作用.

结论:

临床数据表明,ASC对治疗免疫性炎症性疾病,包括严重的COVID-19 ARDS,具有前景.
进一步的研究是必不可少的,以建立关于ASC收集,剂量,管理和临床试验指示的共识.

关键词:

在 COVID-19 疫情中,肺部疾病是一种肺部疾病.介质细胞干细胞介质细胞干细胞

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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...