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Updated: Jul 23, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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作为潜在抗抑郁药的TWIK-1/TREK-1异构体的新型强效阻断剂

Elliot H Lee1, Jung-Eun Park2, Lizaveta Gotina3

  • 1Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Anesthesiology and Pain Medicine, SMG-SNU Boramae Medical Center, College of Medicine, Seoul National University, Seoul, Republic of Korea.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|July 16, 2023
PubMed
概括

研究人员确定了抑制TWIK-1/TREK-1异构体的新型化合物,在小鼠中显示出类似抗抑郁药的效果. 这表明TWIK-1/TREK-1异构体是抗抑郁药物开发的有希望的新标.

关键词:
抗抑郁药是一种抗抑郁药.星球细胞是星球细胞.类似抑郁症的行为富洛克塞提因 (Fluoxetine) 是一种药物.这就是TREK-1的特征.在TWIK-1中,

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