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人类鼻软骨:用于组织工程设计标准的发展的功能性质和结构功能关系

Wendy E Brown¹, Laura Lavernia¹, Benjamin J Bielajew¹

¹Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697, USA.

Acta biomaterialia

|July 16, 2023

概括

这项研究量化了人类鼻的机械和生化特性,为组织工程提供了关键的工程设计标准. 研究结果显示,鼻隔膜,上侧软骨 (ULC) 和下侧软骨 (LLC) 之间的特性存在显著差异.

科学领域:

生物医学工程生物医学工程
组织工程是组织工程.
生物化学生物化学

背景情况:

鼻子重建依赖于软骨移植,但它们的有限可用性需要组织工程解决方案.
了解本地鼻的机械和生物化学特性对于设计有效的工程移植至关重要.

研究的目的:

确定人类鼻腔隔膜,上侧软骨 (ULC) 和下侧软骨 (LLC) 的机械和生物化学特性.
在鼻内建立结构功能关系.
为鼻软骨组织工程提供基本的设计标准.

主要方法:

机械测试 (拉力,聚合模量) 和生物化学分析 (原类型,交叉链接,DNA,糖氨酸糖) 在人类鼻 regions. nasal cartilage上进行.
评估了异异性和性 (原II:原I比率).
组织学染色被用来识别chondrons.

主要成果:

在隔膜,ULC和LLC之间发现了机械特性和生物化学组成的显著差异.
与ULC和LLC相比,隔膜表现出更高的性,聚合模量和最终抗拉强度 (UTS).
在ULC和LLC中确定了机械性质 (拉伸模量,聚合模量) 和生物化学成分 (原,交叉链) 之间的相关性.

结论:

该研究为鼻软骨组织工程提供了关键工程设计标准.
鼻,特别是隔膜,具有相当大的机械特性,表明它可以承受相当大的机械负荷.
这项研究扩大了对鼻的定量理解,有助于未来的移植发育.

关键词:

警报警报警报警报生物化学含量生物化学含量机械性质机械性质鼻子软骨是指鼻子中的软骨.七面体 Septum 七面体是指七面体.上侧面和下侧面的侧面.

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