ACE2基因多态性与先天性心脏病中的肺动脉压力升高有关
Yang Zi-Yang1, Xie Nanshan2, Luo Dongling2
1Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
ангиотензин转化酶2 (ACE2) 单核酸多形态 (SNPs) 影响女性先天性心脏病 (CHD) 患者的肺循环. 特定的ACE2单元型 (CCA,CCG) 与这些患者肺高血压风险降低有关.
科学领域:
- 遗传学和心血管研究
- 肺循环研究 肺循环研究
背景情况:
- ангиотензин转化酶2 (ACE2) 基因变异与心血管疾病的发生和结果有关.
- 在先天性心脏病 (CHD) 中,ACE2多态对肺循环的影响尚不清楚.
- 这项研究的重点是中国汉族CHD患者.
研究的目的:
- 研究ACE2单核酸多形态 (SNPs) 与心脏病患者的肺循环参数之间的关联.
- 确定ACE2 SNPs是否影响心血管疾病中肺高血压的风险.
主要方法:
- 在367名心脏病患者中ACE2SNP (rs2074192,rs2285666,rs2106809) 的基因测序.
- 对被诊断为肺高血压的患者进行详细的血液动力学检查.
- 对基因型和单元型与肺循环血液动力学相关性的分析.
主要成果:
- 与同卵性异卵性患者相比,女性异卵性患者的肺循环血液动力学表现较差.
- 在女性心血管疾病患者中,ACE2的CCA单元型与肺动脉血压升高的风险降低有关 (OR = 0.53).
- 此外,ACE2的CCG单体也显示出对女性心脏病患者肺动脉压升高的保护作用 (OR=0.59).
结论:
- 在患有心血管疾病的女性患者中,ACE2 SNPs与肺循环血液动力学有显著的关系.
- 携带CCA或CCG ACE2单体型的女性心脏病患者患肺高血压的风险较低.
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