治疗模式在男性处方良性前列腺阻塞或过度活跃的膀药物在加拿大:一个回顾性基于人口的研究
Sarah Neu1, Rano Matta1, Jennifer Locke1
1Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Urology
|July 16, 2023
概括
过度活性膀 (OAB) 药物治疗的老年男性比那些良性前列腺阻塞 (BPO) 药物治疗更快地改变了治疗方法. 大多数患者停止了初始治疗,这表明对有效的OAB和BPO治疗的需求尚未得到满足.
科学领域:
- 老年医学 老年医学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度活性膀 (OAB) 和良性前列腺阻塞 (BPO) 是老年男性常见的疾病.
- 目前对OAB和BPO的治疗包括具有不同疗效和副作用的药物.
- 了解治疗模式和医疗保健资源利用对于优化这群人群的护理至关重要.
研究的目的:
- 描述老年男性开始服用OAB或BPO药物的初始治疗变化和医疗资源利用情况.
- 为了比较OAB和BPO药物发起者之间的治疗模式和相关成本.
主要方法:
- 使用加拿大安大略省 (2010-2018) 的卫生行政数据进行的回顾性队列研究.
- 包括年龄≥66岁的男性,有≥1个OAB或BPO药物处方.
- 标志性治疗变化,成本和医疗资源利用率,指数前后日期.
主要成果:
- 与BPO组 (α阻断剂) 相比,OAB组 (抗肌药) 的可能性更高,时间更短,第一次治疗变化.
- 两组中的大多数患者都停止了第一线治疗 (OAB:75.6%; BPO:69.9%).
- 与BPO集团相比,OAB集团在指数前和指数后的平均医疗保健成本较高.
结论:
- 开始服用OAB药物的老年男性往往比开始服用BPO药物的老年男性更快地切换疗法.
- 很大一部分患者在没有后续治疗的情况下停止了第一线OAB和BPO治疗,这表明存在大量未满足的需求.
- 需要进一步的研究来确定OAB和BPO的更有效和更可持续的治疗策略.
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