在牛皮关节炎中药理治疗策略
G Ayan1, A Ribeiro2, Betul Macit3
1Hacettepe University, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey.
Clinical therapeutics
|July 16, 2023
概括
本综述总结了当前的牛皮关节炎 (PsA) 治疗方法,强调了特定领域的疗效和对个性化护理的需求. 根据疾病表型和并发症量身定制治疗对于治疗牛皮关节炎的最佳结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 牛皮病性关节炎 (PsA) 是一种慢性炎症状况,影响关节,皮肤和内.
- 有效的管理需要解决各种疾病领域和相关条件.
研究的目的:
- 介绍当前治疗牛皮关节炎 (PsA) 的治疗策略.
- 为了支持治疗决策,使用基于领域的方法来管理PsA.
主要方法:
- 对PsA治疗策略的叙述性审查.
- 搜索包括PubMed,EMBASE,国际指南和会议摘要.
- 专注于疾病领域:外围关节炎,肠炎,轴性疾病,指甲炎,皮肤/指甲疾病和相关疾病 (阴道炎,IBD).
主要成果:
- 现有多种治疗方法,包括TNF抑制剂,IL-17,IL-12/23,IL-23,JAK抑制剂,阿普雷米拉斯和阿巴塔塞普特.
- 没有任何单一的药物在外围关节炎/牙炎中表现出色;IL-17/IL-12/23抑制剂可能在肠炎中胜过TNF抑制剂.
- IL-17 抑制剂对皮肤PSA表现出优势;TNF 抑制剂在皮膜炎的PSA中是首选的;IL-17 抑制剂应避免在IBD的PSA中使用.
结论:
- 对于PsA,有许多可用的治疗方案,更多的新兴.
- 基于表型,并发症和患者偏好的个性化治疗计划是必不可少的.
- 共享决策是优化牛皮关节炎护理的关键.
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