在三项队列研究中,循环激素和胃癌的风险按次部位分为三种队列研究
Harinakshi Sanikini1, Carine Biessy2, Sabina Rinaldi2
1Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK. h.sanikini@imperial.ac.uk.
概括
与肥胖相关的荷尔蒙如胰岛素样生长因子-1和瘦素会影响心脏胃癌 (CGC) 和非心脏胃癌 (NCGC) 的风险. 格林在男性中显示出与NCGC风险的反向关联.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 肥胖是胃癌的已知危险因素之一.
- 与多余的身体脂肪相关的荷尔蒙失衡与癌症发生有关.
- 肥胖相关激素在心脏胃癌 (CGC) 和非心脏胃癌 (NCGC) 中的具体作用需要进一步阐明.
研究的目的:
- 调查特定与肥胖相关的激素与发展CGC和NCGC的风险之间的关联.
- 进行性别特异性分析,以了解不同的荷尔蒙影响.
- 利用来自大型前性队列研究和生物库的数据来获得可靠的发现.
主要方法:
- 在欧洲癌症和营养前性调查 (EPIC) 和阿尔法-托科菲罗尔,β-胡卜素癌症预防 (ATBC) 研究中进行了嵌套的病例控制研究.
- 在参与者身上测量了血清激素水平.
- 分析了来自UK-Biobank的数据,包括137个CGC和92个NCGC.
- 进行了性别特定的物流和考克斯回归分析,以估计几率比率 (ORs) 和危险比率 (HRs).
主要成果:
- 胰岛素样生长因子-1与男性的CGC和NCGC风险 (EPIC) 和女性的CGC风险 (UK-Biobank) 有积极关联.
- 素 (EPIC男性) 和C- (EPIC女性) 显示出与NCGC风险的积极关联.
- 格林与男性的NCGC风险 (EPIC和ATBC) 相反相关.
- 性激素结合型环球蛋白与英国生物银行男性的CGC有积极的关联;脱水素氨与男性的CGC相反相关 (EPIC和ATBC结合).
结论:
- 与肥胖相关的特定激素显著影响心脏和非心脏胃癌的风险.
- 荷尔蒙途径,包括那些涉及胰岛素样生长因子-1,瘦素,C-, ghrelin 和脱二,在胃癌发生过程中发挥作用.
- 研究结果强调了肥胖,荷尔蒙和胃癌发展之间的复杂相互作用,观察到性别特异性的变化.
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