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以生理学为基础的药物动力学建模来模拟Pyrotinib的CYP3A4-介导药物相互作用

Liang Ni1, Liang Zheng2, Yueyue Liu2

  • 1Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.

Advances in therapy
|July 16, 2023
PubMed
概括

基于生理学上的药理动力学建模预测,与强大的细胞色素P450 3A4 (CYP3A4) 抑制剂同时使用显著增加了pyrotinib的暴露,突出了pyrotinib药物相互作用的风险.

关键词:
在 CYP3A4 中.药物相互作用 药物相互作用建模和模拟的模型和模拟.PBPKK PBPK 的意思是什么意思皮罗丁尼布 (Pyrotinib) 是一种酸盐.

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