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儿科炎性肠病中的静脉血栓栓塞:一个范围审查
Jermie Gandhi1, Keith Mages2, Nicole Kucine3
1From the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Weill Cornell Medicine, New York, NY.
Journal of pediatric gastroenterology and nutrition
|July 17, 2023
概括
儿科炎症性肠病 (pIBD) 患者面临静脉血栓栓塞 (VTE) 的风险. 本综述详细介绍了患有pIBD的儿童VTE预防和管理的当前数据,强调了临床指导方针的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
- 血液学 血液学 血液学
背景情况:
- 儿科炎症性肠病 (pIBD) 可以表现为肠外并发症,包括静脉血栓塞栓症 (VTE).
- 目前缺乏针对儿科IBD患者的VTE预防和治疗的指导方针.
- 本范围审查解决了关于pIBD中VTE的现有数据缺口.
研究的目的:
- 在儿科炎性肠病 (pIBD) 中对静脉血栓栓塞 (VTE) 的文献进行全面的范围审查.
- 详细介绍有关这种脆弱患者群体中VTE的预防和管理策略的现有数据.
主要方法:
- 使用PRISMA扩展范围审查 (PRISMA-ScR) 方法进行了系统的文献搜索.
- 在1967年至2023年间出版的文学作品被识别,选和质量评级.
- 分析了107项涉及216名患有IBD和VTE的儿科患者的研究数据.
主要成果:
- 患有IBD和VTE的儿科患者的中位数年龄为14岁.
- 性结肠炎更为常见 (70%),而VTE通常在诊断后的第一年内发生 (52%).
- 大脑静脉鼻血栓是最常见的VTE类型 (34%),并且在测试患者中 (65%) 发现了高的VIII因子活性.
结论:
- 虽然随机对照试验具有挑战性,但在pIBD中对VTE越来越感兴趣.
- 建议多学科专家发表共识声明.
- 该声明应基于现有的文献和临床经验,以指导管理.
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