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介素-38:牙周炎的关键参与者

Hilal Korkmaz¹, Mükerrem Hatipoğlu¹, Nezahat Arzu Kayar¹

¹Department of Periodontology, Faculty of Dentistry Akdeniz University, Antalya, Turkey.

|July 17, 2023

概括

牙裂液,唾液和血清中的介质白蛋白 (IL) -36γ和IL-38水平与牙周疾病活性相关. 这些生物标志物可能有助于确定牙周炎的进展.

科学领域:

牙周病学牙周病学
生物化学生化学
免疫学免疫学免疫学

背景情况:

牙周炎是一种复杂的炎症性疾病,影响牙和支骨.
矩阵金属蛋白酶-9,IL-17,IL-36γ和IL-38都与炎症过程有关.
了解不同牙周病的生物标志物水平对于诊断和管理至关重要.

研究的目的:

为了比较特定生物标志物的水平 (MMP-9,IL-17,IL-36γ,IL-38) 在牙裂液,唾液和血清.
评估这些生物标志物水平在健康个体,牙炎患者和牙周炎患者.
评估生物标志物水平与临床 parodontal 参数之间的相关性.

主要方法:

研究包括90名志愿者,分为健康,牙炎和牙周炎组.
对所有参与者记录了临床牙周参数.
用酶链接免疫吸收试验分析了牙沟液,唾液和血清样本.

主要成果:

与健康和牙周炎组相比,牙周炎患者的GCF和唾液IL-36γ和IL-38水平显著更高.
在这些生化标志物和临床牙周参数之间观察到正相关性.
与牙周炎组相比,健康组的临床参数明显较低.

结论:

在GCF,唾液和血清中的IL-36γ和IL-38水平与临床牙周参数有关.
这些介质蛋白可以作为牙周炎活动的指标.
进一步的研究可以探索它们在牙周病的诊断和预后价值.

关键词:

在IL-17中,我们可以看到IL-17.的 IL-36γγ.IL-38 这样就好了.在MMP-9中,MMP-9是指MMP-9,MMP-9是指MMP-9.牙裂液牙裂液牙裂液牙周炎是指牙周炎的一种疾病.这是唾液,唾液.血液中的血清是血清.

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