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将轮状病毒疫苗引入中国江省免疫计划的成本效益分析:一个决策树-马尔科夫模型研究

Huakun Lv¹, Fuxing Chen¹, Ying Wang¹

¹Institute of Immunization and Prevention, Zhejiang Center for Disease Control and Prevention, Hangzhou, China.

Human vaccines & immunotherapeutics

|July 17, 2023

概括

五价RotaTeq (RV5) 疫苗在中国预防轮状病毒胃肠炎 (RVGE) 的成本效益高于单价RV疫苗 (RV1). RV5提供了更高的价值,以更低的成本避免更多的残疾调整寿命年 (DALYs).

科学领域:

公共卫生公共卫生
卫生经济学卫生经济学
疫苗学疫苗学疫苗学

背景情况:

两种轮状病毒 (RV) 疫苗,五价值的RotaTeq (RV5) 和单价值的RV疫苗 (RV1),已在中国江省获得许可.
评估这些疫苗的成本效益对于优先考虑省级免疫计划至关重要.

研究的目的:

在5年的时间内,评估和比较RV1和RV5疫苗接种计划与没有RV疫苗接种的成本效益.
在中国的省级免疫策略中为RV疫苗的纳入提供政策决策的信息.

主要方法:

采用决策树-马尔科夫模型来模拟不同RV疫苗接种场景的成本和健康结果 (DALYs被避免).
对成本效益的评估是根据支付意愿 (WTP) 门进行评估,该门定义为江省人均GDP (在2021年为16865.70美元).
进行了敏感性分析 (单向和概率分析),以评估研究结果的可靠性.

主要成果:

在基准情景中,RV5表现出卓越的成本效益,每DALY的增量成本为510.00美元.
尽管提供了可比的健康益处,但RV1显示了更高的成本效益比率,即每天避免4600美元,尽管提供了可比的健康益处.
在WTP值,RV5的成本效益概率为88.4%,而RV1.3的成本效益为72.3%.
预计使用RV1或RV5的RV疫苗接种将使门诊访问,住院和RVGE死亡减少30-70%.

结论:

五价RotaTeq (RV5) 疫苗是江省预防轮状病毒的最具成本效益的选择.
使用RV1或RV5实施RV疫苗接种计划极有可能具有成本效益,并显著减少轮状病毒胃肠炎的负担.

关键词:

罗塔病毒 (Rotavirus) 是一种病毒.经济效益性经济效益性疫苗接种计划免疫计划模型模型模型模型模型模型疫苗疫苗疫苗疫苗

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