在瑞典以人口为基础的查计划的两轮之后,使用便免疫化学测试中的性别特定切断水平进行间隔癌症
Hanna Ribbing Wilén1, Johannes Blom1
1Department of Clinical Science and Education Södersjukhuset (KI SÖS), Karolinska Institutet, Stockholm, Sweden.
Journal of medical screening
|July 17, 2023
概括
结直肠癌查中的性别特异性便免疫化学测试 (FIT) 切断值显示,男性和女性的间隔癌症发病率相似. 妇女的FIT水平较低可能是由于癌症的近位位置较多.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 基于人口的结直肠癌 (CRC) 查计划利用便免疫化学测试 (FIT) 来检测疾病.
- 优化查策略通常涉及评估性别特异性参数,以提高检测率和减少间隔癌症 (ICs).
研究的目的:
- 在瑞典基于人口的查计划的两个轮之后评估间隔癌症 (IC) 率,使用性别特定的FIT截止值.
- 为了比较测试灵敏度,IC率和IC发病率相对于性别之间的背景CRC发病率.
主要方法:
- 在2015-2019年期间邀请参加查的60至69岁人士的纳入.
- 适用性别特定的FIT截止值:女性40μg/g,男性80μg/g.
- 使用瑞典结肠直肠癌登记处检测到的查CRCs (SD CRCs) 和ICs的验证,随访两年.
主要成果:
- 在第二轮查中,在229,187名受邀个人中,诊断出193例SD CRC和144例IC.
- IC率为8.9,测试灵敏度为0.61,显示性别之间的相似性.
- 虽然男性的整体IC率较高,但与背景CRC发病率相对的IC发病率在两轮治疗中在两种性别中都相似.
结论:
- 与男性和女性背景CRC发病率相比,相似的间隔癌症发病率支持性别特定的查策略.
- 在CRC女性中观察到较低的FIT水平,特别是在近端瘤中,可能解释了这些发现.
- 对性别特异性瘤特征和FIT性能进行进一步的研究是有必要的.
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