肝移植后骨折的危险因素:一个基于人口的队列研究
Jei-Wen Chang1,2,3, Hui-Hsin Yang3,4, Niang-Cheng Lin3,5
1Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan.
Annals of medicine
|July 17, 2023
概括
肝移植患者面临更高的骨折风险,特别是老年人,女性接受者有先前的骨折,C型肝炎,酒或高剂量的普雷迪尼索隆. 塔克罗利斯和西罗利斯/埃弗洛利斯的使用可能会降低骨折风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
- 整形外科 整形外科 整形外科
背景情况:
- 肝移植接受者对骨质疏松症和骨折的易感性增加.
- 确定移植后骨折的特定风险因素对于患者管理至关重要.
研究的目的:
- 调查台湾人口中肝移植接受者的骨折相关的风险因素.
- 为预防策略提供信息,并改善肝移植患者的治疗结果.
主要方法:
- 从台湾国家医疗保险研究数据库 (2003-2015) 中确定了一组肝移植接受者.
- 考克斯的比例危险模型被用来分析移植后骨折的风险因素.
主要成果:
- 在4821名接受者中,8.7%的人经历了移植后骨折.
- 独立的危险因素包括年龄≥65,女性性别,先前的骨折,C型肝炎,酒以及较高的普雷迪尼索隆剂量.
- 塔克罗利斯和西罗利斯/埃弗洛利斯的使用显示出对骨折的保护作用.
结论:
- 高龄,女性性别,先前的骨折史,C型肝炎,酒以及高剂量的普雷尼索隆会增加移植后骨折的风险.
- 塔克罗利斯和西罗利斯/埃弗洛利斯的使用与肝移植接受者的骨折风险降低有关.
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