血清尿酸和前列腺癌死亡率在抗雄激素缺乏治疗中的关联:基于人口的队列研究
Yan Hiu Athena Lee1,2, Jeffrey Shi Kai Chan1, Chi Ho Leung2
1Cardio-oncology Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China.
Cancer medicine
|July 17, 2023
概括
在接受雄激素剥夺疗法 (ADT) 的前列腺癌 (PCa) 患者中,高基线尿酸 (UA) 水平与增加PCa死亡风险有关. 低UA水平显示出一种保护性关联,但在进一步分析中,这并不重要.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 流行病学 流行病学
背景情况:
- 前列腺癌 (PCa) 是男性死亡的一个重要原因.
- 安卓素剥夺疗法 (ADT) 是PCa的常见治疗方法.
- 在ADT期间基线尿酸 (UA) 水平在PCa结果中的作用需要进一步调查.
研究的目的:
- 为了研究基线尿酸 (UA) 水平和前列腺癌 (PCa) 相关死亡率在接受雄激素剥夺疗法 (ADT) 的患者之间的关联.
主要方法:
- 一项基于人口的队列研究包括4126名PCa患者,他们在1999年12月至2021年3月期间在香港接受ADT.
- 缺少基线UA水平的患者被排除在外.
- 随访持续到2021年9月,首要结果是PCa相关的死亡率.
主要成果:
- 在基线UA和PCa相关死亡率之间观察到J形关联.
- 高于平均水平的UA水平 (≥0.401 mmol/L) 与PCa死亡率增加35%的风险相关 (HR 1.35;95% CI 1.21-1.51).
- 低于平均水平的UA水平显示出与死亡率的反向关联 (HR 0.78;95% CI 0.67-0.92),这在竞争风险分析中没有显著意义.
结论:
- 基线尿酸水平与ADT患者的PCa相关死亡率呈现J形关系.
- 升高的UA水平与增加的PCa死亡风险显著相关.
- 需要进一步的研究来验证这些发现,并探索潜在的混因素.
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