在中枢神经系统疾病中植物性天然化物的研究进展
Qingqing Zhang1, Qinghua Jiang2, Kuiru Sa1
1Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Phytotherapy research : PTR
|July 17, 2023
概括
来自植物的天然类化合物为治疗中枢神经系统 (CNS) 疾病提供了更安全的替代品. 本综述总结了120种类化合物,探讨了它们的潜在治疗应用以及中枢神经系统药物开发的未来方向.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 自然产品化学 自然产品化学
背景情况:
- 中枢神经系统 (CNS) 疾病是导致复杂病变的首要死亡原因.
- 目前的中枢神经系统药物治疗通常可以控制症状,并且可能产生不良影响.
- 来自植物的天然化合物,特别是类化合物,呈现出有希望的更安全和更有效的治疗替代品.
研究的目的:
- 审查具有针对中枢神经系统疾病的已证明活性的天然化物.
- 探索这些类化合物的来源,结构,作用机制和结构-活性关系.
- 确定从天然类化合物中开发新型中枢神经系统药物的趋势和未来前景.
主要方法:
- 对具有中枢神经系统活动的天然类化合物进行全面的文献搜索.
- 根据它们的植物来源对类化合物的分类.
- 分析化学结构,作用机制和结构-活性关系.
- 120种相关类化合物的摘要.
主要成果:
- 确定了120种具有潜在中枢神经系统治疗作用的化物.
- 收集了有关来源,结构多样性和行动机制的详细信息.
- 讨论了潜在的药物设计的结构-活性关系见解.
结论:
- 天然类化合物是开发新型中枢神经系统疾病治疗的丰富来源.
- 对它们的机制和结构-活性关系的进一步研究可以指导开发更安全,更有效的中枢神经系统药物.
- 这一综述为未来在天然化物基础上的神经疗法领域的研究提供了基础.
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