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在唾液腺囊性癌症中TIM-3/Galectin-9和CD160的表达

Mao Li¹, Zi-Xin Wan¹, Yue-Yang Tang¹

¹State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

|July 17, 2023

概括

含有T细胞免疫球蛋白和含有-3 (TIM-3),Galactin 9 (Gal-9) 和CD160的粘素域在唾液腺囊性癌症 (SACC) 中被上调. 它们的表达与SACC复发和病理分类相关,表明潜在的治疗点.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

唾液腺囊性癌 (SACC) 是一种罕见的恶性瘤.
了解瘤微环境对于开发有效疗法至关重要.

研究的目的:

研究TIM-3,Gal-9和CD160在SACC中的表达.
分析这些标记物,瘤透淋巴细胞 (TILs) 和SACC的临床病理特征之间的相关性.

主要方法:

在60个SACC病例中,免疫组织化学染色被用于评估TIM-3,Gal-9和CD160表达.
使用统计分析 (等级和值测试,奇平方测试) 来评估相关性.

主要成果:

TIM-3和CD160的过度表达与SACC复发相关 (p=0.029,p=0.007).
高的Gal-9表达与病理学分类相关 (p=0.018).
在瘤细胞和TIL中发现了TIM-3,Gal-9和CD160表达之间的正相关性.

结论:

低TIL密度是SACC微环境的特征,同时对TIM-3,Gal-9和CD160.0进行上调.
依赖于TILs的TIM-3,Gal-9和CD160表达在层体中,代表了SACC的潜在治疗点.

关键词:

CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 CD160 盖尔-9-9是什么意思这就是TIM-3的意义.免疫组织化学疗法唾液腺囊性癌瘤入瘤的淋巴细胞

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