酵母β-葡萄糖调节巨细胞并改善癌症NK细胞抗瘤反应
Zhichao Zhu1, Liuyang He1, Yu Bai1
1Laboratory of Oncology, Medical Research Center, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
Clinical and experimental immunology
|July 17, 2023
概括
酵母衍生的全β-葡萄糖颗粒 (WGPs) 将与瘤相关的巨细胞 (TAMs) 重新编程为抗瘤M1表型. 这增强了自然杀手 (NK) 细胞的活性,导致瘤在体内增长的延迟.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 巨细胞是瘤中的关键免疫细胞,其表型影响瘤进展.
- 重编程巨细胞是癌症免疫治疗的一个有希望的策略.
研究的目的:
- 研究酵母衍生的全β-葡萄糖颗粒 (WGP) 对巨细胞两极分化和抗瘤免疫的作用.
- 阐明NK细胞在WGP介导的抗瘤作用中的作用.
主要方法:
- 实验室内对巨细胞极化和NK细胞激活的研究.
- 在体内研究中,使用带有瘤的小鼠接受了口服WGP治疗.
- 评估免疫细胞种群,巨细胞表型和瘤生长.
- 进行NK细胞枯竭实验以评估它们的作用.
主要成果:
- WGPs诱导M0巨细胞分化为M1巨细胞,并将M2巨细胞和TAM转化为M1.
- 用WGP治疗的巨细胞增强了NK细胞激活受体和细胞毒性.
- 口服WGP通过增加巨细胞和NK细胞,逆转巨细胞表型,并促进NK细胞功能来延缓瘤生长.
- NK细胞的枯竭降低了WGP的治疗疗效.
结论:
- WGPs有效地将巨细胞重新编程为一种抗瘤M1表型.
- 通过巨细胞重编程和随后的NK细胞功能增强,WGP增强了抗瘤免疫力.
- 除了T细胞之外,NK细胞在WGP的抗瘤作用中发挥着至关重要的作用.
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