遗传性血栓友病:未被发现的并发症使COVID-19感染复杂化
Divya Khatana1, Poonam Rani1, Swati Jain1
1Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital Delhi, India.
American journal of blood research
|July 17, 2023
概括
未被诊断的血栓性疾病,特别是蛋白C和S缺乏,与严重的COVID-19结局有关. 这些血栓,以及较高的抗COVIDIgG抗体标位,即使在康复后,在严重病例中也更为普遍.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- COVID-19严重程度与未诊断的血栓性疾病之间的关系尚不清楚.
- 血栓ophilia可能会加剧COVID-19中的血栓状态,可能导致严重的疾病.
- 在COVID后的患者中调查血栓友爱概况可以阐明疾病严重性因素.
研究的目的:
- 在康复的患者中分析潜在的血栓形成症和COVID-19严重程度之间的关联.
- 为了比较重症与非重症COVID-19病例中的血栓友爱概况.
- 评估与疾病严重程度相关的COVID后抗体标位.
主要方法:
- 选择了一个由40名严重和40名非严重的COVID-19患者组成的队列,至少在康复后6周.
- 评估了血栓友爱查,全血细胞计和抗COVIDIgG抗体标位.
- 统计分析包括使用Stata软件 (版本13) 进行Chi-square和Student的t测试.
主要成果:
- 17.5%的患者进行了血栓友爱检查,结果呈阳性.
- 在严重的COVID-19患者中,蛋白C缺乏 (15%) 和蛋白S缺乏 (17.5%) 显着更高.
- 严重病例显示了统计学上显著的更高的蛋白C (P=0.002),蛋白S (P=0.007) 和抗COVIDIgG抗体标位 (P=0.0001).
结论:
- 蛋白C和S缺乏是严重COVID-19患者常见的异常.
- 一个阳性血栓性特征和高的抗COVIDIgG标位与严重的COVID-19感染相关.
- 潜在的血栓友可能是导致COVID-19疾病严重程度的因素,甚至在康复后.
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