精液的参数经过静脉瘤切除手术与巨细胞稳定剂治疗在不育的静脉瘤患者:随机临床试验研究研究
Alireza Akhavan Rezayat1, Amirmohammad Soleimanian2, Neda Kamandi2
1Department of Urology Mashhad University of Medical Sciences Mashhad Iran.
Health science reports
|July 17, 2023
概括
静脉切除术与基托提芬结合,可显著改善患有静脉的不孕男性的精子参数. 这种组合疗法在减少精子DNA碎片化方面比单独的静脉切除术或基托提芬更有效.
科学领域:
- 生殖医学 生殖医学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 不孕症研究 不孕症研究
背景情况:
- 静脉是男性不孕症的主要原因,导致丸逐渐受损.
- 精子DNA碎片化是男性静脉患者生殖功能受损的关键指标.
研究的目的:
- 评估静脉切除术和大细胞稳定剂 (ketotifen) 在改善精液质量和减少精子DNA碎片化的有效性,在患有静脉的不孕男性.
- 为了比较单独的静脉切除术,单独的凯托蒂芬和组合治疗的有效性.
主要方法:
- 一项随机临床试验,涉及420名患有静脉的不孕男性.
- 参与者被分配到三个组:静脉瘤切除术,1毫克基托芬,或静脉瘤切除术加1毫克基托芬3个月.
- 精液分析和精子DNA碎片化指数 (DFI) 在干预前后进行评估.
主要成果:
- 所有治疗组均显示精子形态,运动性,计数和DFI (p <0.05) 的显著改善.
- 与单独治疗两种疗法相比,静脉切除术加上基托芬的组合表明精液参数在统计学上有更好的改善 (p < 0.01).
结论:
- 静脉切除术和基托蒂芬的联合治疗对于改善静脉男不孕男性的精液参数更有效.
- 这种结合的方法提供了一个有前途的策略,用于管理男性不孕症与水结核相关.
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