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神经组织工程预血管化in vivo增强通过快速血管内毒素的外周神经再生

Hongkui Wang¹, Ping Zhang¹, Panjian Lu¹

¹Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, JS, 226001, PR China.

Materials today. Bio

|July 17, 2023

概括

这项研究介绍了一种预先血管化的组织工程神经移植 (TENG),可以克服血管化的挑战. 创新的TENG促进神经再生和功能恢复在周围神经缺陷.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
神经科学是一个神经科学.

背景情况:

血管化是组织工程神经移植 (TENGs) 的临床转化的一个关键障碍.
现有的TENG很难模仿复杂的自然血管系统,限制了它们在修复神经缺陷方面的有效性.

研究的目的:

开发和评估用于外围神经修复的皮下预血管化的TENG.
在大鼠坐骨神经缺陷模型中评估预血管化的TENG的功能整合和再生能力.

主要方法:

使用酸盐导管,丝纤维蛋白纤维和血管内皮生长因子诱导的主体血管网络构建TENG.
利用对比剂输液,微CT扫描和3D重建来确认血管功能.
进行了组织学和电生理学评估,以评估神经修复效率.

主要成果:

在TENG和宿主血管之间在4天内实现了快速的血管免疫.
由于早期血管化,表现出增强的轴突再生,施万细胞迁移和布恩格纳带形成.
观察到显著改善的remyelination,电生理功能,和预防肌肉缩在12周.

结论:

在神经组织工程中,TENGs的皮下预血管化是一种可行的策略,可以克服神经组织工程中的血管化限制.
这种方法促进神经再生,促进功能恢复,并为个性化的TENG发展提供了一个有希望的途径.

关键词:

神经再生是一种神经再生.周围神经受伤的情况.血管化前期的进行.组织工程神经移植组织工程神经移植血管内静脉注射 (Vascular inosculation) 是一种血管内静脉注射.

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