对内在因子的自身抗体可能危及恶性贫血的诊断:一个病例报告
Lucía Fraile1, Ana Sopena1, Carlos E Chávez1
1Servicio de Análisis Clínicos, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
EJIFCC
|July 17, 2023
概括
维生素B12测试中的技术干扰可能会使诊断复杂化,可能导致恶性贫血的误诊. 对这些干扰的认识对于准确的患者评估和避免不必要的侵入性手术至关重要.
科学领域:
- 临床化学 临床化学
- 血液学 血液学 血液学
- 神经学 神经学
背景情况:
- 维生素B12缺乏可以表现为严重的神经和血液问题.
- 准确测量维生素B12对于诊断与缺乏相关的疾病至关重要.
- 临床实验室广泛提供维生素B12水平测试.
研究的目的:
- 突出技术干扰对维生素B12测定精度的影响.
- 报告一个干扰导致诊断挑战和差点误诊的病例.
- 强调在临床实践中识别测试干扰的重要性.
主要方法:
- 病例报告详细介绍了一名疑似患有恶性贫血的患者.
- 对维生素B12测量结果的分析.
- 由于测试干扰而进行的诊断程序的审查.
主要成果:
- 在维生素B12测试中发生了技术干扰.
- 这种干扰需要进一步的侵入性调查.
- 患者几乎被误诊,尽管患有恶性贫血.
结论:
- 维生素B12测定中的技术干扰可能导致诊断延迟和错误.
- 临床医生必须意识到潜在的干扰,以确保准确的诊断.
- 识别测定局限性对于适当的患者管理和避免不必要的程序至关重要.
相关概念视频
Gastritis-II: Pathophysiology
380
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
380
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
357
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
357
Autoimmune Disorders
511
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
511
Vitamins
802
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
802
Myasthenia Gravis: Diagnostic Tests
1.0K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.0K
Chronic Pancreatitis I: Introduction
116
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
116


