怀孕测试日血清孕激素度可能预测经过受控卵巢刺激和新鲜胚胎移植后正在进行的怀孕
Marie Duport Percier1, Sophie Brouillet2,3, Caroline Mollevi4
1Department of Reproductive Medicine, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Frontiers in endocrinology
|July 17, 2023
概括
怀孕测试日血清孕水平可以预测IVF后流产风险. 水平低于16.5 ng/mL的女性可能会从延长的状期支持中受益,以改善妊娠结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
- 辅助生殖技术 辅助生殖技术
背景情况:
- 对试管婴儿进行的受控卵巢刺激 (COS) 可以导致白期缺陷.
- 状期支持 (LPS) 至少在怀孕测试日之前至关重要.
- 有时使用延长的LPS,但最佳持续时间仍在争论中.
研究的目的:
- 调查怀孕测试日血清孕激素 (P4) 水平是否可以预测新鲜胚胎移植后的怀孕结果.
- 为了确定P4水平是否可以识别可能受益于长期质期支持的女性.
主要方法:
- 一个追溯研究99个试管婴儿周期与新鲜胚胎移植和阳性怀孕测试.
- 标准的质阶段支持 (微化阴道孕激素600毫克/天15天) 被管理.
- 血清P4水平是在卵细胞检索后的第15天 (怀孕测试日) 测量.
主要成果:
- 与流产 (<12周) 相比,正在进行的怀孕 (>12周) 中P4水平的中位数显著更高 (55.9 ng/mL与18.1 ng/mL).
- 一个P4度≥16.5 ng/mL与明显更高的持续怀孕率 (OR=12.5) 和活产率 (OR=11.88) 相关.
结论:
- 在怀孕测试日的血清P4水平是预测新鲜胚胎移植后怀孕成功的有价值生物标志物.
- 患P4水平<16.5 ng/mL的女性可能有更高的流产风险,并可能受益于个性化,延长的期支持.
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