阿尔法-阿米林作为抗生物膜剂对抗抗甲素耐药和万科米辛中间体黄金葡萄球菌
Pooi Yin Chung1, Pey Lin Narissa Loh1, Hui-Min Neoh2
1School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
Heliyon
|July 17, 2023
概括
阿尔法-阿米林 (AM) 显示出降低黄金葡萄球菌 (Staphylococcus aureus) 的生物膜生物质的潜力,包括耐药菌株. 这种天然化合物可能为慢性感染提供新的治疗途径.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 黄金葡萄球菌感染是由于抗菌素耐药性而造成的全球健康威胁.
- 细菌生物膜可以保护金黄色菌免受抗菌剂的侵害,从而使治疗复杂化.
- 阿尔法-阿米林 (AM) 之前已经显示出对基准菌株的抗菌膜活性.
研究的目的:
- 评估阿尔法-阿米林 (AM) 对*黄金葡萄球菌*的临床分离物的抗菌膜活性.
- 评估AM在对甲基西林敏感的*S. aureus* (MSSA),对甲基西林耐药的*S. aureus* (MRSA) 和米素中间的*S. aureus* (VISA) 生物膜上的疗效.
- 研究AM对生物膜生物质和代谢活动的影响.
主要方法:
- 使用了MSSA,MRSA和VISA的临床分离物.
- 预先形成的生物膜被用AM,万科米辛或西林治疗.
- 生物膜生物质量用水晶紫色试验量化.
- 代谢活动通过resazurin测定来评估.
主要成果:
- 在MSSA,MRSA和VISA分离物中减少了AM生物膜生物质.
- 在某些MSSA,MRSA和VISA分离物中AM增加了代谢活性.
- 亚美证明了生物膜减少效应,但没有杀菌效应.
结论:
- 阿尔法-阿米林对包括耐药性菌株在内的各种*S. aureus*菌株表现出抗菌膜特性.
- 艾滋病病毒可能是开发新疗法治疗慢性黄金色杆菌感染的有希望的候选人.
- 进一步研究AM作为治疗剂是有必要的.
关键词:
阿尔法-阿米林的使用.生物膜是一种生物膜.甲基西林耐药的金黄色葡萄球菌 (Staphylococcus aureus) 是一种黄金葡萄球菌 (Staphylococcus aureus) 是一种菌素中间体.更多相关视频
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