前带状皮层和轨道前皮层的太振荡在灵活的奖励学习中差异调节准确度和速度
Tony Ye1, Juan Luis Romero-Sosa1, Anne Rickard1
1Department of Psychology, UCLA, Los Angeles, CA 90095, USA.
Oxford open neuroscience
|July 17, 2023
概括
灵活的奖励学习涉及额叶皮质. 抑制前带状皮质 (ACC) 损害了逆向学习,突出了ACC在审议和达信号准确性中的作用.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
背景情况:
- 灵活的奖励学习对于适应行为至关重要.
- 前带状皮质 (ACC) 和轨道前皮质 (OFC) 是关键的前部区域.
- 泰达振荡 (5-10 Hz) 与协调学习有关,但ACC-OFC网络相互作用仍然不清楚.
研究的目的:
- 在灵活学习过程中调查ACC和OFC之间的网络级互动.
- 确定ACC度振荡在刺激-奖励关联学习和逆转中的作用.
主要方法:
- 在老鼠的背部ACC和腹部OFC中同时进行的in vivo电生理学.
- 双边抑制DREADDs可以抑制ACC功能.
- 在主题内设计,评估视觉歧视和逆向学习期间的准确性和响应速度.
主要成果:
- 在早期逆转学习中,ACC抑制导致随机响应.
- 正确和不正确的试验之间的theta功率差异仅在OFC,而不是ACC中,在抑制后显著.
- 与对照动物不同的是,ACC抑制在逆转学习过程中加速了不正确的选择.
结论:
- 在ACC抑制后逆转学习受损的特点是缺乏深思熟虑和薄弱的信号传递.
- OFC θ振荡是反向学习的一个突出特征,独立于ACC活动.
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