生物量子:数据处理软件,用于同时对元素和分子进行成像分析,使用两个质谱仪
Toshihiro Suzuki1, Hui Hsin Khoo1,2, Takafumi Hirata1
1Geochemical Research Center, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Mass spectrometry (Tokyo, Japan)
|July 17, 2023
概括
一个新的数据处理软件,BioQuant,通过对准两个质谱仪的离子检测时间,实现了同时进行元素和分子成像. 这种方法允许在单个样本中的元素和分子之间进行准确的相关性分析.
科学领域:
- 分析化学 分析化学
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 同时进行元素和分子分析对于全面的样本表征至关重要.
- 由于检测时间不同,现有的方法在调整不同质谱仪的数据方面面临挑战.
研究的目的:
- 开发一种新的数据处理方法,用于准确的同时元素和分子成像.
- 为了使单个样本中的元素和分子丰度之间进行可靠的相关性分析.
主要方法:
- 使用分流协议将激光诱导的样本颗粒引入无机和有机质谱仪.
- 开发了BioQuant软件来纠正离子检测信号的时间差异.
- 将来自多个单元单元的信号强度数据合并到基于共同时间间隔的统一单元单元中.
主要成果:
- 通过使用BioQuant软件,成功对准了两个质谱仪的飞行时间数据.
- 能够计算单个样本材料中元素和分子之间的丰度相关性.
- 证明了对元素和分子分布的同时成像的能力.
结论:
- 生物量子软件,激光除和双质谱的结合为集成的元素和分子成像提供了一个基准技术.
- 这种方法克服了先前与单独分析的元素和分子数据相关的局限性.
- 促进复杂的生物和材料样本的先进多模式分析.
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