患有痴呆症的住院老年患者中COVID-19相关死亡率的预测因素
Vasiliki Epameinondas Georgakopoulou1,2, Aikaterini Gkoufa1, Aristeidis Tsakanikas1
1Department of Infectious Diseases and COVID-19 Unit, Laiko General Hospital, Medical School, 11527 Athens, Greece.
Experimental and therapeutic medicine
|July 17, 2023
概括
由于COVID-19肺炎而住院的痴呆症老年患者面临高死亡率. 缺乏完整的疫苗接种和年龄较大是不良结果的独立预测因素,包括住院期间和90天内死亡.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 患有痴呆症的老年患者因COVID-19肺炎的死亡率很高.
- 关于这一脆弱群体在整个流行病期间的结果的数据有限.
- 了解风险因素对于改善护理和治疗结果至关重要.
研究的目的:
- 研究因COVID-19肺炎住院的痴呆症老年患者的临床特征.
- 在所有流行病阶段确定住院和90天死亡率.
- 确定这个群体中死亡率的独立预测因素.
主要方法:
- 在2021年2月至2022年7月期间,对105名因COVID-19肺炎住院的痴呆症老年患者 (≥65岁) 的回顾性分析.
- 数据收集包括患者人口统计,疫苗接种状态和住院结果.
- 统计分析,包括单变量和多变量回归,用于确定死亡率预测因素.
主要成果:
- 整体住院死亡率为36.2%,90天死亡率为49.5%.
- 在Omicron变种期间,住院率更高 (49.5%).
- 没有充分接种疫苗是住院 (HR 5.182) 和90天死亡率 (HR 3.286) 的独立预测因素. 高龄也与90天死亡率独立相关 (HR 1.047).
结论:
- 由于COVID-19肺炎而住院的痴呆症老年患者在医院和90天死亡率高.
- 完全接种疫苗的状态是降低死亡风险的关键因素.
- 年龄较大独立地预测了这个患者群体的较差结果.
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