与注射可用的帕利佩里相关的反弹类
Bamidele O Johnson1, Godwin Orji1, Olayemi O Johnson2
1Psychiatry, Interfaith Medical Center, Brooklyn, USA.
Cureus
|July 17, 2023
概括
帕利佩里是一种抗精神病药物,可以悖论地在精神分裂症患者中诱导猫. 这一案例凸显了药物诱导的猫的罕见但严重的风险,需要仔细监测.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 帕利佩里是一种非典型的抗精神病药物,用于治疗精神分裂症,精神分裂情绪障碍和双相情感障碍.
- 它通过阻断多巴胺D2受体来起作用.
- 副作用包括额外皮拉米德症状,体重增加和代谢问题,罕见但严重的情况如.
研究的目的:
- 报告与长效注射型帕利皮里治疗相关的罕见白内障病例.
- 强调抗精神病药物有可能导致或恶化触动性症状.
主要方法:
- 案例报告的呈现方式.
- 关于药物诱导的猫的文献综述.
主要成果:
- 该病例涉及一个患有精神分裂症的患者,他在长期使用注射性帕利佩里时出现了.
- 矛盾的是,抗精神病药物可以诱导或加剧猫,17-19%的医学诱导猫病例与药物相关.
结论:
- 卡塔托尼亚是一种严重的神经精神综合征,其特点是精神运动障碍.
- 对于这种可能危及生命的疾病,迅速识别和管理至关重要.
- 这一案例强调了在分辨性诊断中考虑药物副作用 (包括帕利佩里) 的重要性.
相关概念视频
Antiepileptic Drugs: Potassium Channel Activators
215
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
215
Psychosis: Goals of Pharmacotherapy
170
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
170
Mania and Antimanic Drugs: Overview
249
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
249
Desensitization and Tachyphylaxis
1.8K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.8K
Psychosis and Antipsychotic Drugs: Overview
336
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
336
Depolarizing Blockers: Pharmocokinetics
353
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
353


