末期脏病患者的血homocysteine水平和心血管事件:系统性审查
Abdulilah A ALSolami1, Abdulrhman A Almalki2, Saleh Yousef Alhedyan3
1Nephrology, King Fahad Armed Forces Hospital, Jeddah, SAU.
Cureus
|July 17, 2023
概括
高水平的homocysteine (Hcy) 在末期病 (ESRD) 患者中很常见,可以预测心血管事件. 需要进一步的研究来澄清ESRD人群中这种复杂的关系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 临床营养学 临床营养学
背景情况:
- 患有慢性病的患者面临来自心血管疾病 (CVD) 的高死亡风险.
- 过高homocysteinemia,一个高homocysteine水平的情况,经常观察到末期病 (ESRD) 患者.
- 这种高水平的homocysteine可能会增加对心血管并发症的易感性.
研究的目的:
- 系统地审查ESRD患者的同类氨酸水平和心血管事件之间的关联.
- 探索维生素补充剂在减轻心血管或死亡风险方面的潜在作用.
主要方法:
- 在PubMed,Science Direct和Google Scholar (2003-2023) 中进行了全面的文献搜索.
- 关键词包括"同氨酸"",末期脏病"",心血管事件"和"维生素补充剂".
- 纳入标准集中在研究ESRD患者的Hcy-CVD关联和维生素补充效应的研究上.
主要成果:
- 该综述包括11项研究 (2003-2023年) 与3,953名参与者 (79.15%男性).
- 十项研究报告了心血管死亡率或事件 (例如心肌梗塞,中风).
- 大多数患者表现出较高的总同型半氨酸 (tHcy) 水平,总共记录了817次心血管疾病事件.
结论:
- 在ESRD患者中,同类半氨酸与心血管事件之间的联系是复杂的,需要进一步调查.
- 同类氨酸可以作为ESRD中心血管事件的预测剂.
- 营养因素和并发症可能会影响同类氨酸与患者结局之间的关联.
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