在被诊断患有·维勒布兰德病的人群中药理治疗焦虑和抑郁症:匹配的队列研究
Katrina Wilcox Hagberg1, Susan Jick1,2, Gülden Özen3
1Boston Collaborative Drug Surveillance Program, Lexington, MA, 02421, USA.
Journal of blood medicine
|July 17, 2023
概括
患有·维勒布兰德病 (VWD) 的人患有治疗焦虑和抑郁症的比率更高. 患有VWD的年轻女性尤其面临这些心理健康状况的风险.
科学领域:
- 血液学 血液学 血液学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- ·威尔布兰德病 (VWD) 与生活质量降低有关.
- 关于VWD患者焦虑和抑郁的患病率的证据有限.
研究的目的:
- 调查·威尔布兰德病 (VWD) 与心理健康结果之间的关联.
- 为了确定VWD诊断是否会增加焦虑和抑郁的风险.
主要方法:
- 使用英国临床实践研究数据链接 (CPRD) GOLD数据库 (1988-2016) 的回顾性队列研究.
- 根据性别,出生年份和实践细节,VWD患者与没有VWD的对照进行1:10匹配.
- 诊断/匹配日期后的随访,以确定治疗焦虑和抑郁症 (诊断代码+90天内的药物).
主要成果:
- 在8.0%的VWD患者和6.0%的对照组中观察到治疗焦虑 (IRR1.37,95%CI1.10-1.71).
- 在11.0%的VWD患者和8.6%的对照组中观察到治疗抑郁症 (IRR 1.35,95%CI 1.11-1.63).
- 年轻女性 (0-39岁) 患有治疗焦虑和抑郁症的风险最高.
结论:
- 与没有VWD的人相比,被诊断患有VWD的人患有治疗焦虑和抑郁症的发病率更高.
- 在VWD患者中,精神健康状况的风险增加在年轻女性中尤为明显.
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