持续性能的测试有助于诊断中风后认知障碍在右半球损伤的患者
XiuLi Li1,2, FuBiao Huang1,2, TieJun Guo1,2
1Faculty of Rehabilitation, Capital Medical University, Beijing, China.
Frontiers in neurology
|July 17, 2023
概括
患有右半球损伤 (RHD) 的患者在认知任务期间在前额叶皮质 (PFC) 中表现出较慢的神经补偿. 持续性表现测试 (CPT) 可能有助于诊断这些患者中风后认知障碍 (PSCI).
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 脑卒中后认知障碍 (PSCI) 是一个重大挑战,特别是在右半球损伤 (RHD) 的患者中.
- 了解RHD认知缺陷的神经基础对于有效的诊断和治疗至关重要.
研究的目的:
- 在对照组和患有PSCI的RHD患者之间,研究氧化血红蛋白 (Oxy-Hb) 在前额叶皮层 (PFC) 变化的时间进程.
- 评估持续性表现测试 (CPT) 的可行性,以诊断和评估RHD患者的PSCI.
主要方法:
- 功能近红外谱学 (fNIRS) 在CPT期间测量了PFC中的Oxy-Hb度变化.
- 16名RHD患者和32名对照参与了这项研究;用蒙特利尔认知评估尺度评估认知功能.
主要成果:
- 与对照组相比,RHD患者的准确性和命中率较低,CPT反应时间较长.
- 虽然整体PFC活性没有显著差异,但在RHD组中,正确的PFC中心点值更高.
- 氧化Hb的时间过程不同,显示RHD患者受影响的PFC区域的神经补偿速度较慢.
结论:
- CPT显示出作为诊断RHD患者PSCI的临床工具的潜力.
- 此外,CPT对于监测这一群体认知干预措施的有效性也可能是有价值的.
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