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封装瘤集群的血管在肝细胞癌中的血管模式

Ken Liu^1,2,3, Claude Dennis¹, David S Prince⁴

¹Australian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

JHEP reports : innovation in hepatology

|July 17, 2023

概括

封装瘤集群的血管 (VETC) 是攻击性肝癌 (HCC) 的生物标志物. 这种模式可以预测疾病复发和存活率,指导治疗决策以获得更好的患者结果.

科学领域:

在瘤学瘤学.
血管生物学血管生物学
肝细胞癌研究肝细胞癌研究

背景情况:

封装瘤集群的血管 (VETC) 代表了与新型转移机制相关的独特组织血管模式.
在2004年首次在人类癌症中被发现,VETC在肝细胞癌 (HCC) 中的作用在过去十年中得到了显著的关注.
VETC被认为是侵袭性疾病的生物标志物,通过对瘤组织的组织学检查来诊断.

研究的目的:

审查肝细胞癌 (HCC) 中VETC的患病率和预后意义.
探索VETC作为HCC的诊断和预测生物标志物的潜力.
讨论VETC对HCC治疗策略和精准医学的影响.

主要方法:

组织学检查瘤组织用于VETC诊断.
对VETC患病率和HCC的预后意义的现有文献的分析.
对VETC模式的放射性识别进步的审查.
评估VETC对治疗反应的预测价值 (例如,跨动脉化学栓塞,索拉芬尼布).

主要成果:

在接受切除或移植的HCC患者中,VETC始终被确定为疾病复发和整体存活率的独立预测因子.
VETC可以预测患者对跨动脉化学栓塞和索拉芬尼布等疗法的反应.
射线识别VETC是一个活跃的研究领域,准确度越来越高.

结论:

在HCC中,VETC是一种强大的预后标志物,表明疾病具有侵略性.
虽然VETC可以指导治疗,但最终的建议需要前性试验.
鉴于其与瘤血管新生和免疫微环境的联系,VETC具有重要的潜力,作为未来的生物标志物,用于推进HCC的精密医学.

关键词:

封装瘤集群的血管 (VETC)血管新生是因为血管新生.生物标志物生物标志物表皮介质介质过渡 (EMT)肝移植肝移植肝移植转移转移转移转移

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