预测性营养指数的预测价值,对于晚期心力衰竭患者的长期死亡率
Selahattin Turen1, Kadriye Memic Sancar1
1Cardiology Department, Health Sciences University Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training Research Hospital, Istanbul, Turkey.
Acta Cardiologica Sinica
|July 17, 2023
概括
预后营养指数 (PNI) 有效预测晚期心力衰竭 (HF) 患者的长期死亡率. 低PNI是该人口中所有原因和心血管死亡率的重要独立预测因素.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 预测 预测 预测 预测 预测
背景情况:
- 营养不良在晚期心力衰竭 (HF) 中很普遍,导致患者的治疗结果差.
- 晚期HF和营养不良都与高死亡风险有关.
研究的目的:
- 评估预后营养指数 (PNI) 作为高级HF患者长期死亡率的预测指标.
- 确定营养状况对该群体死亡率的预测值.
主要方法:
- 一项追溯观察性研究,涉及217名晚期HF患者.
- 通过ROC分析确定最佳PNI切线为50.5,将患者分为低 (≤50.5) 和高 (>50.5) PNI组.
- 多变量考克斯回归分析以确定死亡率的独立预测因素.
主要成果:
- 与高PNI (86.7%和89.6%) 相比,低PNI患者在所有原因 (24.6%) 和心血管死亡 (36.1%) 中的5年生存率明显较低.
- 低PNI (HR:4.70) 和高敏感性C反应蛋白 (hsCRP) (HR:1.02) 是所有原因死亡率的独立预测因素.
- 低PNI (HR:4.52),hsCRP (HR:1.01) 和NYHA类IV (HR:2.56) 独立预测心血管死亡率.
结论:
- 预后营养指数 (PNI) 是高级HF中长期所有原因和心血管死亡率的独立预测指标.
- PNI 作为一种简单,客观的工具,用于高级心力衰竭患者的风险分层.
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